C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors
نویسندگان
چکیده
منابع مشابه
The Pseudomonas aeruginosa exoenzyme Y impairs endothelial cell proliferation and vascular repair following lung injury.
Exoenzyme Y (ExoY) is a Pseudomonas aeruginosa toxin that is introduced into host cells through the type 3 secretion system (T3SS). Once inside the host cell cytoplasm, ExoY generates cyclic nucleotides that cause tau phosphorylation and microtubule breakdown. Microtubule breakdown causes interendothelial cell gap formation and tissue edema. Although ExoY transiently induces interendothelial ce...
متن کاملDownregulation of HMGB1 by miR-103a-3p Promotes Cell Proliferation, Alleviates Apoptosis and Inflammation in a Cell Model of Osteoarthritis
Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. Objectives: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. Materials an...
متن کاملStructural basis of Rho GTPase recognition by C3 exoenzyme
C3 exoenzyme is a mono-ADPribosyltransferase (ART) that catalyzes transfer of an ADP-ribose moiety from NAD to Rho GTPases. C3 has long been used to study the diverse regulatory functions of Rho GTPases. How C3 recognizes its substrate and ADP-ribosylation proceeds are still poorly understood. Crystal structures of C3-RhoA complex reveal that C3 recognizes RhoA via switch I, switch II and inter...
متن کاملVimentin Mediates Uptake of C3 Exoenzyme
Clostridium botulinum C3 exoenzyme (C3) selectively inactivates RhoA/B/C GTPases by ADP-ribosylation. Based on this substrate specificity C3 is a well-established tool in cell biology. C3 is taken up by eukaryotic cells although lacking an uptake and translocation domain. Based on different approaches vimentin was identified as membranous C3-interaction partner by mass spectrometry. Vimentin in...
متن کاملThe Effect of Gaillardin on Proliferation and Apoptosis of Acute Lymphoblastic Leukemia Cell Line (Nalm-6)
Background: Due to increased cancer chemotherapy resistance, the use of natural compounds in cancer treatment has been considered in recent years. Inula-Oculus-Christi, is one of the high importance plants in the field of traditional medicine. It has been shown that extract of this plant has cytotoxic effects on breast cancer cells. Objective: Therefore, the aim of this study was to evaluate t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Naunyn-Schmiedeberg's Archives of Pharmacology
سال: 2016
ISSN: 0028-1298,1432-1912
DOI: 10.1007/s00210-016-1270-2